Asthma Allergy Centre Research Group
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Asthma Allergy Centre Research Group is actively engaged in clinical research
involving areas such as asthma, sinus problems, and backflow of nasal
secretion into tear ducts during nose blowing.
In recent years we have made several important discoveries.
We and our colleagues at Kaiser Permanente have discovered one kind of
asthma that was previously unknown. In some asthmatic patients, the asthma
usually started with a cold or sinus infection, and the asthma episodes, which
can be mild or very severe requiring hospitalizations, lasted for a few months
to many years. The asthma then gradually became milder and finally
recovered. However, after an asthma-free period of a few months to several
years, another prolonged episode occurred again following another cold or
sinus infection. The research results were published in a medical journal
CHEST.
We and our colleagues at Kaiser Permanente also have investigated the
accuracy of the diagnosis of asthma. In a group of patients who were referred
to us for the diagnosis and management of their difficult to control asthma
symptoms, we found that 20% of them did not have asthma. So, many
diseases can mimic asthma and present to us with diagnostic and
management difficulty. The research results were presented at the Annual
Meeting of the American Academy of Allergy, Asthma and Immunology, and
appeared in the Journal of Allergy and Clinical Immunology.
In March 2006, we presented a research result that was previously unknown at
the Annual Meeting of the American Academy of Allergy, Asthma and
Immunology at Miami Beach, Florida. We found that the tear duct is not a
one-way duct just to drain tears into nose, as it has always been assumed. We
discovered that in over 50% of subjects, the fluorescent eye solution that was
instilled into their nose appeared in the eyes when the nose was blown. The
research found that there is a back flow of nasal secretion into eyes through
tear ducts when a person blows his or her nose. The research results also
appeared in Journal of Allergy and Clinical Immunology. In clinical practice, we
have "cured" many patients' chronic or recurrent red, itchy eyes, particularly with
crusty eyelashes at arising when they stopped blowing their nose. The nasal
allergies or sinus problem were treated and their nasal snot was removed
with a nasal irrigation solution.